If your gut could make a playlist, 2025 would be all hits, no skips.

This year, study after study dropped in L. reuteri research, and honestly? We weren’t surprised. Science keeps confirming what we’ve believed all along. L. reuteri is a powerhouse probiotic that your body needs.

With Zoguri, we’ve always let science lead the way. Every spoonful of our fermented L. reuteri yogurt delivers two keystone strains (DSM 17938 and ATCC PTA 6475) plus five more beneficial bacteria that play in harmony to support digestion, immunity, and overall wellness.

But we don’t just rely on customer stories to support Zoguri’s impact. We keep an eye on the research, and 2025 gave us plenty to smile about. From faster recovery after stomach bugs to stronger bones post-surgery, L. reuteri proved why it’s one of the most studied probiotics on the planet.

So, grab a Zogi-spoon and settle in… here’s your 2025 “L. reuteri Research Roundup.”

JANUARY
H. pylori Doesn't Stand a Chance
Have you ever had a stomach infection that required antibiotics? If so, you know the treatment can feel almost as bad as the problem itself. Adding L. reuteri for digestive support helps you feel better while your body heals.

Researchers analyzed seven studies with 518 patients to see if adding L. reuteri to standard H. pylori treatment (the bacteria that causes stomach ulcers) made a difference. The results were encouraging. People who took L. reuteri alongside their antibiotics had fewer side effects like diarrhea and constipation, and their infection cleared more effectively.¹

FEBRUARY
Intellectual Support for Tiny Humans
Extremely preterm infants (born at 23-27 weeks) face some of the biggest developmental challenges of all, including higher risks for cognitive and language delays. In this study, researchers gave babies L. reuteri DSM 17938 for 36 weeks and followed up when the children turned two. The results? While most growth measurements were similar between groups, the L. reuteri group scored significantly higher in language development.²

That’s a big deal. Language skills are one of the strongest indicators of healthy brain development, and this study demonstrates just how far-reaching L. reuteri’s benefits may be, even from the earliest stages of life. 

MARCH
Stomach Bugs, Meet Your Match
Children with acute gastroenteritis recovered faster with L. reuteri DSM 17938. By day three, only 14.5% still had watery diarrhea compared to 82.9% in the placebo group.³

Parents everywhere, rejoice! L. reuteri may help those tough tummy days pass more quickly.

APRIL
Getting Nerdy with Inflammation (Animal Edition)
Not all of L. reuteri’s superpowers show up in the gut; some of the most fascinating research happens in the lab, where scientists are exploring how this probiotic might influence inflammation throughout the body. Two animal studies this spring took that curiosity to the next level. In rats with spinal cord injuries, L. reuteri DSM 17938 helped calm inflammation, improved movement recovery, and supported healing by modulating tryptophan metabolism - a key pathway linked to both mood and immune health.⁴

Meanwhile, another study found that L. reuteri produces a compound called indole-3-acetic acid (IAA), which helped reduce inflammation and inhibit tumor development in mouse models of colorectal cancer.⁵

While these are early, preclinical findings, they highlight something exciting: L. reuteri’s benefits may reach far beyond digestion - potentially influencing everything from inflammation to recovery to long-term cellular health.

MAY
Quality of Life Matters
Children with cystic fibrosis took L. reuteri daily for 12 weeks. While the study didn't show major changes in most symptoms, quality-of-life scores improved significantly in the probiotic group compared to placebo.⁶

Living with a chronic condition is tough, especially for children. Sometimes the best benefit isn’t dramatic; it’s simply feeling a little better every day.

THEME OF THE YEAR: DIGESTIVE SUPPORT

From June through August, one pattern was crystal clear: L. reuteri yogurt supports a healthier, happier gut, especially when antibiotics or illness throw it off balance.

JUNE
Less Diarrhea for Children During Antibiotic Treatment
In a study of 720 children, L. reuteri DSM 17938 helped prevent antibiotic-associated diarrhea. Children taking it had fewer episodes, and when they did get diarrhea, it didn’t last as long.⁷

Antibiotics can provide big benefits, but they can also wreak havoc on gut health. This large-scale study shows L. reuteri can protect childrens' microbiomes while its fighting infections.

JULY
Rotavirus Recovery, Accelerated
If you’ve ever had a little one down with rotavirus, you know it’s rough - days of diarrhea, dehydration, and exhaustion, for both the children and their parents. It’s one of the leading causes of severe diarrhea in young children worldwide, and even with standard treatment, recovery can take time.

In this study, children who received L. reuteri DSM 17938 alongside standard therapy cleared the infection significantly faster and showed higher levels of helper T cells afterward, a key sign of stronger immune function.⁸

That’s the power of a probiotic working double-duty: faster recovery and a more resilient immune system. It’s another reminder that L. reuteri doesn’t just help your gut bounce back, it helps your body stay ready for what’s next.

AUGUST
Acute Diarrhea, Defeated Within 48 Hours
Thai children with acute diarrhea received L. reuteri DSM 17938 for 5 days. The probiotic group had shorter diarrhea duration, and significantly more children recovered within 48 hours compared to the control group.⁹

This adds to the growing evidence that L. reuteri speeds up recovery when digestive issues strike. Whether it's from antibiotics, viruses, or general GI upset, the pattern is clear: this strain works.

SEPTEMBER
Your Gums Will Thank You
Adults with gingival inflammation (a precursor to gum disease) took L. reuteri daily for eight weeks and the results were impressive.¹⁰ Participants saw meaningful reductions in inflammatory markers and less bone loss around the gums, signaling better oral health overall.

It’s fascinating to see a probiotic typically known for gut health showing benefits in the mouth, too. The more we learn about L. reuteri, the clearer it becomes that your gut isn’t working alone.

OCTOBER
From Surgery to Smiles: Faster Recovery with L. reuteri
Patients recovering from tooth extraction started taking L. reuteri DSM 17938 within 24 hours post-surgery and continued for 8 weeks. The probiotic group had higher bone density, greater oral microbial diversity, and significantly reduced inflammation markers compared to controls.¹¹

Dental surgery recovery can be painful and slow. L. reuteri appears to speed healing and reduce inflammation. Great news for anyone facing tooth extraction! 

NOVEMBER & DECEMBER
Stay Tuned...
The year’s not quite over, and knowing L. reuteri, there’s probably more to come.

WHAT THIS YEAR TAUGHT US

If 2025 had a theme, it was this: L. reuteri offers so many benefits for whole-body health that we are just scratching the surface on discovering them all. From digestion and immunity to oral health and recovery across all age groups, the research keeps reinforcing what we’ve seen in real life; daily L. reuteri supplementation can make a big difference.

If you’re looking to introduce L. reuteri into your wellness routine, Zoguri delivers both keystone L. reuteri strains (ATCC PTA 6475 and DSM 17938) plus five other beneficial bacteria in every serving of our fermented probiotic yogurt, to support your gut microbiome from every angle. Try Zoguri today, and see why it has become part of so many people's daily routines.

Here's to more breakthroughs in 2026!

 

 

¹Elkoumi, Omar, et al. "P-96. Efficacy and Safety of Lactobacillus Reuteri Supplementation Combined with Triple Therapy for Eradicating Helicobacter Pylori: An Updated Meta-Analysis of Randomized Controlled Trials." Open Forum Infectious Diseases, vol. 12, no. Supplement_1, 29 Jan. 2025.

²Wejryd, Erik, et al. "Neurodevelopment and Growth 2 Years after Probiotic Supplementation in Extremely Preterm Infants: A Randomised Trial." Acta Paediatrica, vol. 114, no. 8, 13 Feb. 2025, pp. 1817–1824.

³Iramain, Ricardo, et al. "Lactobacillus Reuteri Protectis DSM 17938 at High Doses versus Placebo in Children with Acute Gastroenteritis in a Pediatric Emergency Department." Journal of Pediatric Gastroenterology and Nutrition, 3 Mar. 2025.

⁴Cen, et al. ”Limosilactobacillus Reuteri DSM 17938 Attenuates Neuroinflammatory Responses After Spinal Cord Injury by Modulating Tryptophan Metabolism.” Probiotics and Antimicrobial Proteins, 26 Apr. 2025.

⁵Wang, et al. ”Gut Microbiota–Derived Indole-3-Acetic Acid Ameliorates Precancerous Inflammatory Intestinal Milieu to Inhibit Tumorigenesis through IL-35.” Journal for ImmunoTherapy of Cancer, vol. 13, no. 4, 23 Apr. 2025, p. e011155.

⁶Rahmani, Parisa, et al. ”The Impact of Probiotics on Pulmonary, Gastrointestinal, and Growth Outcomes in Pediatric Cystic Fibrosis: A Randomized Controlled Trial." BMC Pediatrics, vol. 25, no. 1, 28 May 2025.

⁷Ener Cagri Dinleyici, et al. ”Effect of Limosilactobacillus Reuteri DSM17938 to Prevent Antibiotic-Associated Diarrhea in Children: Prospective, Multi-Center, Randomized, Placebo-Controlled Clinical Trial (PEARL Study)." European Journal of Pediatrics, vol. 184, no. 7, 9 June 2025.

⁸He, Zhihua, et al. ”The Efficacy of Lactobacillus Reuteri in Conjunction with Racecadotril in Managing Pediatric Rotavirus Enteritis and Its Impact on Intestinal Mucosa and Immune Function.”  African Health Sciences, vol. 25, no. 2, 15 July 2025, pp. 38–45.

⁹Rerksuppaphol, Lakkana, and Sanguansak Rerksuppaphol. ”Efficacy of Lactobacillus Reuteri DSM 17938 in Thai Children with Acute Gastroenteritis and Normal or Mild Dehydration in an Outpatient Setting: A Randomized Controlled Trial.” Journal of Tropical Pediatrics, vol. 71, no. 4, 7 August 2025.

¹⁰Lu, Jian, et al. ”Clinical Effects of Lactobacillus Reuteri on Gingival Inflammation and Alveolar Bone Loss in Periodontitis.”  Oral Health & Preventive Dentistry, vol. 23, Sept. 2025, pp. 585–591.

¹¹Fu, Dongjie, et al. ”Probiotics Enhance Bone Density and Reduce Inflammation Postalveolar Surgery,” International Dental Journal, vol. 75, no. 5, Oct. 2025, p. 100881.