How Zoguri May Support Your Health in Reducing Sickness and Enhancing Immunity

Introduction

Why do those taking Zoguri seem to get sick less often? We’ve seen this trend in both the customer reviews—as well as supported by the clinical trials on the strains of L. reuteri (Limosilactobacillus Reuteri) found in Zoguri. Customers have experienced significantly less sick days from upper respiratory infections and gastrointestinal (GI) issues. So how do the probiotic strains selected for Zoguri boost immunity?

Zoguri, L. reuteri, and Immunity
Zoguri, our L. reuteri yogurt-based supplement, has been crafted to replenish what could be missing in your digestive system. The seven species of beneficial bacteria in Zoguri, including two strains of L. reuteri—a beneficial keystone species that 96% of modern-day humans lack1—have been clinically shown to promote healthy digestion2; lessen symptoms of constipation3 and irritable bowel syndrome (IBS)4; support immunity5 and bone health6; and reduce stress,7 anxiety,7 and inflammation.8

So how do the bacteria in Zoguri work to support the reduction in illness duration? Several ways, but the individual strains of probiotics really matter. Here we want to focus on our two keystone strains of L. reuteri that we’ve hand-picked based on clinical evidence. L. reuteri probiotic bacteria have garnered significant attention for their health benefits. Among its various strains, Zoguri includes L. reuteri 6475 and L. reuteri 17938, which stand out for their unique properties in reducing sickness and boosting immunity. Let’s explore the mechanisms through which these strains exert their beneficial effects.

The Strains Matter

L. reuteri 6475

L. reuteri 6475 has been extensively studied for its anti-inflammatory and immune-modulating properties. This strain is known to produce reuterin, a broad-spectrum antimicrobial substance that inhibits the growth of pathogenic bacteria in the gut. By maintaining a balanced gut microbiota, L. reuteri 6475 helps prevent infections and support overall gut health.8

Additionally, L. reuteri 6475 has been shown to enhance the production of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune responses.9 This immunomodulatory effect helps to reduce chronic inflammation and improves the body's ability to fight off infections.

L. reuteri 17938

L. reuteri 17938 is derived from the same parent strain as 6475 and shares many of its beneficial properties, but it also has its own unique advantages. This strain is particularly effective in managing GI disorders such as colic, diarrhea, and constipation.3,4 By producing lactic acid and other metabolites, L. reuteri 17938 creates an acidic environment in the gut that inhibits the growth of harmful bacteria. Research indicates that it can enhance the gut barrier function, reducing intestinal permeability and preventing the translocation of pathogens into the bloodstream.10 This protective effect is crucial in preventing systemic infections and maintaining overall immune health.

Synergistic Effects and Clinical Applications

Mother and Daughter

When used together, L. reuteri 6475 and 17938 create a synergistic effect that enhances their individual benefits. Clinical studies demonstrate that these strains can reduce the incidence and severity of respiratory infections, improve gut health, and enhance overall immune function.4,5

For example, a study involving children with acute gastroenteritis found that supplementation with L. reuteri 17938 significantly reduced the duration of diarrhea and resulted in improved recovery times. Similarly, adults with IBS reported reduced symptoms and improved quality of life when taking L. reuteri 6475.

Conclusion

L. reuteri 6475 and 17938 are powerful probiotic strains with proven benefits in reducing sickness and enhancing immunity. Their ability to modulate the gut microbiota, enhance gut barrier function, and regulate immune responses makes them valuable tools in promoting health and preventing disease. As research continues to uncover the full potential of these probiotics, their clinical applications are likely to expand, offering new hope for individuals seeking natural ways to boost their immune health.


 

1 Molin G, Jeppsson B, Johansson ML, et al. Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines. J Appl Bacteriol. 1993;74(3):314-323. doi: 10.1111/j.1365-2672.1993.tb03031.x 
2 Gao, H, Li X, Chen X, et al. The functional roles of Lactobacillus acidophilus in different physiological and pathological processes. J Microbiol Biotechnol. 2022;32(10):1226-1233. doi:10.4014/jmb.2205.05041 
3 Riezzo G, Orlando A, D’Attoma B, et al. Randomised double-blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation." Benef Microbes. 2018;9:1:51-60.  https://doi.org/10.3920/BM2017.0049 
4 Cruchet S, Hirsch S, Villa-López D, et al. Limosilactobacillus reuteri DSM 17938 and ATCC PTA 6475 for the treatment of moderate to severe irritable bowel syndrome in adults: a randomized controlled trial. Front Gastroenterol. 2024. doi: 10.3389/fgstr.2023.1296048 
5 Tubelius P, Stan V, Zachrisson A. Increasing workplace healthiness with the probiotic Lactobacillus reuteri: a randomized, double-blind placebo-controlled study. Environ Health. 2005;4:25. doi: 10.1186/1476-069X-4-25 
6 Nilsson AG, Sundh D, Bäckhed F, Lorentzon, M. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind clinical trial. J Intern Med. 2018;284(3):307-317. doi: 10.1111/joim.12805 
7 Schaub AC, Schneider E, Vazquez-Castellanos JF, et al. Clinical, gut microbial, and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial. Transl Psychiatry. 2022;12. Accessed February 15, 2025. https://doi.org/10.1038/s41398-022-01977-z 
8 Li P, Ji B, Luo H, et al. One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density. NPJ Biofilms Microbiomes. 2022;8(1):84. doi: 10.1038/s41522-022-00348-2 
9 Mesilhy S. 9 Lactobacillus reuteri health benefits: digestive, testicular, and oral. Probiotic Review Girl. Accessed February 15, 2025. https://probioticreviewgirl.com/lactobacillus-reuteri/
10 König J, Roca Rubio MF, Forsgård RA, et al. The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D—an exploratory RCT. PLOS One. 2024;19(11):e0312464. https://doi.org/10.1371/journal.pone.0312464
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